Our team gathers clinicians and scientists to address relevant clinical questions, focused on the study of kidney and liver graft transplantation, and of autoimmune diseases, mostly multiple sclerosis, with a basic and translational approach. Common objectives as well as common tools historically link these two topics in our team. Thanks to the establishment of bio-collections and databases, we have been able to investigate the role of T and B lymphocytes in theses two pathological settings. The key challenges and the achievements of our team to improve patient’s health and their quality of life are highlighted in our project.
Kidney transplantation, accounting for 60% of total transplants, remains the major treatment for end- stage renal diseases. A better understanding of the mechanisms of graft survival, such as the role of immune cells but also the establishment of regulatory mechanisms, is required to optimize therapy by personalizing treatments, to identify effective biomarkers of graft survival and to decrease the use of immunosuppressant drugs. Multiple sclerosis is a disabling disease mostly affecting young adults due to inflammatory lesions of the central nervous system. As in transplantation and overall in autoimmune diseases, T and B lymphocytes play a key role in multiple sclerosis pathophysiology The precise phenotype of these populations, their antigen specificities and their pathogenic role remain to be addressed. Our research activity is based on two main axes, a transversal axis devoted to the research of biomarkers of the pathology (transplantation and autoimmune diseases) and a second one devoted to the dissection of immune mechanisms involving CD8+ T cells and B regulatory cells, and to the development of innovative therapeutic strategies to induce immune regulation/tolerance in these pathologies.